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Plant degradomicsComplex molecular mechanisms enable plants to recognize prevailing environmental conditions and cope with abiotic and biotic challenges. We are studying the function of the hundreds of plant proteases in this context, with a focus i) on the role of proteases in determining the outcome of plant-microbe interactions and ii) on proteostasis in plastids and mitochondria.
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Proteolysis in health and diseaseDeregulated proteolysis is involved in the pathogenesis and progression of many human diseases. In close collaboration with clinicians and clinical researches we are aiming to discriminate normal from pathologic processes and aim to identify substrate of proteases implicated in disease.
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Mass spectrometry method developmentMass spectrometry enables identification and quantification of thousands of proteins in complex samples and is therefore the ideal tool to obtain unbiased insights into protease function. We specialize in the development of new degradomics methods for sensitive detection of proteolytic activities, but also improve standard workflows, e.g. by establishing new digestion proteases for bottom-up proteomics, and contribute to multimodal mass spectrometry imaging of biomolecules in biological tissues.
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