Protease Degradomics
  • Home
  • Team
    • Lab Alumni
    • Visiting Scientist
    • Open Positions
  • Research
    • Plant degradomics
    • Proteolysis in health and disease
    • Method development
  • Publications
  • Contact
Picture

Plant degradomics

Complex molecular mechanisms enable plants to recognize prevailing environmental conditions and cope with abiotic and biotic challenges. We are studying the function of the hundreds of plant proteases in this context, with a focus i) on the role of proteases in determining the outcome of plant-microbe interactions and ii) on proteostasis in plastids and mitochondria.

Picture

Proteolysis in health and disease

Deregulated proteolysis is involved in the pathogenesis and progression of many human diseases. In close collaboration with clinicians and disease experts we investigate proteolytic processes in health and disease.

Picture

Mass spectrometry method development

Mass spectrometry enables identification and quantification of thousands of proteins in complex samples and is therefore the ideal tool to obtain unbiased insights into protease function. We specialize in the development of new degradomics methods for sensitive detection of proteolytic activities, but also  improve standard workflows, e.g. by establishing new digestion proteases for bottom-up proteomics, and contribute to multimodal mass spectrometry imaging of biomolecules in biological tissues. 
Powered by Create your own unique website with customizable templates.
  • Home
  • Team
    • Lab Alumni
    • Visiting Scientist
    • Open Positions
  • Research
    • Plant degradomics
    • Proteolysis in health and disease
    • Method development
  • Publications
  • Contact