New tools and methods

We are interested in tools such as degradomics methods that allow detection of post-translationally modified proteoforms in vivo. This includes characterization and application of new enzymes such as LysargiNase to obtain information that is missed by standard tryptic digests.

Plant degradomics

Plants contain hundreds of proteases. But which proteins are cut, when and where? What is the physiological role of proteolytically modified proteoforms? We study these questions from all angles, including unbiased system-wide profiling approaches.

Proteolysis in health and disease

Deregulated proteolysis is involved in the pathogenesis and progression of many human diseases. In close collaboration with clinicians and disease experts we utilize our methods to characterize proteolytic processes in health and disease.

Mass spectrometry imaging

Where are proteins located in complex tissues such as brain and how do they
correlate with the distributions of lipids, other biomolecules and elements?
We address this by mass spectrometry imaging.