Mass spectrometry method development

We are interested in new mass spectrometry tools that allow identification, quantification and localization of biomolecules in vivo. This ranges from mass spectrometry imaging over characterization of novel digestion proteases for bottom-up proteomics to development of next generation degradomics methods for sensitive detection of proteolytically modified proteoforms. 

Plant degradomics

Plants contain hundreds of proteases. But which proteins are cut, when and where? What is the physiological role of proteolytically modified proteoforms? We study these questions from all angles, including unbiased system-wide profiling approaches.

Proteolysis in health and disease

Deregulated proteolysis is involved in the pathogenesis and progression of many human diseases. In close collaboration with clinicians and disease experts we utilize our methods to characterize proteolytic processes in health and disease.