Plants as sessile organism have evolved intricate molecular mechanisms to cope with dramatically changing environmental conditions and challenge by pathogens. We study how proteases determine the outcome of plant-microbe interactions, and how proteases help plants to cope with abiotic stress.
Deregulated proteolysis is involved in the pathogenesis and progression of many human diseases. In collaboration with clinicians and clinical researchers we are aiming to discriminate normal from pathologic processes and aim to identify substrate of proteases implicated in disease.
Mass spectrometry enables identification and quantification of thousands of proteins in complex samples and is therefore the ideal tool to obtain unbiased insights into protease function. We
develop new degradomics methods for sensitive detection of proteolytic activities, but also adapt and improve standard workflows, e.g. by use of new digestion proteases.